| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPME1 (1-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPME1 |
| Gene ID: |
51400 |
| Uniprot ID: |
PPME1_HUMAN |
| Immunogen Region: |
1-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PPME1 (NP_057231.1). |
| Immunogen Sequence: |
MSALEKSMHLGRLPSRPPLP GSGGSQSGAKMRMGPGRKRD FSPVPWSQYFESMEDVEVEN ETGKDTFRVYKSGSEGPVLL LLHGGGHSALSWAVFTAAII SRVQCRIVALDLRSHGETKV KNPEDLSAETMAKDVGNVVE AMYGDLPPPIMLIGHSMGGA |
| Post Translational Modifications | Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1. |
| Function | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. |
| Protein Name | Protein Phosphatase Methylesterase 1Pme-1 |
| Database Links | Reactome: R-HSA-69273 |
| Alternative Antibody Names | Anti-Protein Phosphatase Methylesterase 1 antibodyAnti-Pme-1 antibodyAnti-PPME1 antibodyAnti-PME1 antibodyAnti-PP2593 antibodyAnti-PRO0750 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
