| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4695RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2000-1:20000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPM1A |
| Gene ID: | 5494 |
| Uniprot ID: | PPM1A_HUMAN |
| Immunogen Region: | 1-382 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human PPM1A (NP_066283.1). |
| Immunogen Sequence: | MGAFLDKPKMEKHNAQGQGN GLRYGLSSMQGWRVEMEDAH TAVIGLPSGLESWSFFAVYD GHAGSQVAKYCCEHLLDHIT NNQDFKGSAGAPSVENVKNG IRTGFLEIDEHMRVMSEKKH GADRSGSTAVGVLISPQHTY FINCGDSRGLLCRNRKVHFF TQDHKPSNPLEKERIQNAGG SVMIQRVNGSLAVSRALGDF DYKCVHGKGPTEQLVSPEPE VHDIERSEEDDQFIILACD |
| Post Translational Modifications | N-myristoylation is essential for the recognition of its substrates for dephosphorylation. |
| Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. |
| Protein Name | Protein Phosphatase 1aProtein Phosphatase 2c Isoform AlphaPp2c-AlphaProtein Phosphatase Ia |
| Database Links | Reactome: R-HSA-2173795Reactome: R-HSA-380972 |
| Cellular Localisation | NucleusCytoplasmCytosolMembraneLipid-AnchorWeakly Associates At The Membrane And N-Myristoylation Mediates The Membrane Localization |
| Alternative Antibody Names | Anti-Protein Phosphatase 1a antibodyAnti-Protein Phosphatase 2c Isoform Alpha antibodyAnti-Pp2c-Alpha antibodyAnti-Protein Phosphatase Ia antibodyAnti-PPM1A antibodyAnti-PPPM1A antibody |
Information sourced from Uniprot.org