| Function | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. |
| Protein Name | Inositol Hexakisphosphate And Diphosphoinositol-Pentakisphosphate Kinase 1Diphosphoinositol Pentakisphosphate Kinase 1Histidine Acid Phosphatase Domain-Containing Protein 2aIp6 KinaseInositol Pyrophosphate Synthase 1Insp6 And Pp-Ip5 Kinase 1Vip1 HomologHsvip1 |
| Database Links | Reactome: R-HSA-1855167 |
| Cellular Localisation | CytoplasmCytosolCell MembraneRelocalizes To The Plasma Membrane Upon Activation Of The Ptdins 3-Kinase Pathway |
| Alternative Antibody Names | Anti-Inositol Hexakisphosphate And Diphosphoinositol-Pentakisphosphate Kinase 1 antibodyAnti-Diphosphoinositol Pentakisphosphate Kinase 1 antibodyAnti-Histidine Acid Phosphatase Domain-Containing Protein 2a antibodyAnti-Ip6 Kinase antibodyAnti-Inositol Pyrophosphate Synthase 1 antibodyAnti-Insp6 And Pp-Ip5 Kinase 1 antibodyAnti-Vip1 Homolog antibodyAnti-Hsvip1 antibodyAnti-PPIP5K1 antibodyAnti-HISPPD2A antibodyAnti-IP6K antibodyAnti-IPS1 antibodyAnti-KIAA0377 antibodyAnti-VIP1 antibody |
Information sourced from Uniprot.org
