| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POU3F2 (1-68) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POU3F2 |
| Gene ID: |
5454 |
| Uniprot ID: |
PO3F2_HUMAN |
| Immunogen Region: |
1-68 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human POU3F2 (NP_005595.2). |
| Immunogen Sequence: |
MATAASNHYSLLTSSASIVH AEPPGGMQQGAGGYREAQSL VQGDYGALQSNGHPLSHAHQ WITALSHG |
| Tissue Specificity | Expressed specifically in the neuroectodermal cell lineage. |
| Function | Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes. |
| Protein Name | Pou Domain - Class 3 - Transcription Factor 2Brain-Specific Homeobox/Pou Domain Protein 2Brain-2Brn-2Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3Octamer-Binding Protein 7Oct-7Octamer-Binding Transcription Factor 7Otf-7 |
| Database Links | Reactome: R-HSA-9619665 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pou Domain - Class 3 - Transcription Factor 2 antibodyAnti-Brain-Specific Homeobox/Pou Domain Protein 2 antibodyAnti-Brain-2 antibodyAnti-Brn-2 antibodyAnti-Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3 antibodyAnti-Octamer-Binding Protein 7 antibodyAnti-Oct-7 antibodyAnti-Octamer-Binding Transcription Factor 7 antibodyAnti-Otf-7 antibodyAnti-POU3F2 antibodyAnti-BRN2 antibodyAnti-OCT7 antibodyAnti-OTF7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
