| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLR3C |
| Gene ID: |
10623 |
| Uniprot ID: |
RPC3_HUMAN |
| Immunogen Region: |
1-270 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human POLR3C (NP_006459.3). |
| Immunogen Sequence: |
MTQAEIKLCSLLLQEHFGEI VEKIGVHLIRTGSQPLRVIA HDTGTSLDQVKKALCVLVQH NLVSYQVHKRGVVEYEAQCS RVLRMLRYPRYIYTTKTLYS DTGELIVEELLLNGKLTMSA VVKKVADRLTETMEDGKTMD YAEVSNTFVRLADTHFVQRC PSVPTTENSDPGPPPPAPTL VINEKDMYLVPKLSLIGKGK RRRSSDEDAAGEPKAKRPKY TTDNKEPIPDDGIYWQANL |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner. |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc3Rna Polymerase Iii Subunit C3Dna-Directed Rna Polymerase Iii Subunit CRna Polymerase Iii 62 Kda SubunitRpc62 |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase Iii Subunit Rpc3 antibodyAnti-Rna Polymerase Iii Subunit C3 antibodyAnti-Dna-Directed Rna Polymerase Iii Subunit C antibodyAnti-Rna Polymerase Iii 62 Kda Subunit antibodyAnti-Rpc62 antibodyAnti-POLR3C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
