| Short Description : | Rabbit polyclonal POLG2 (216-485) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POLG2 |
| Gene ID: | 11232 |
| Uniprot ID: | DPOG2_HUMAN |
| Immunogen Region: | 216-485 |
| Immunogen Sequence: | HPVFDTKQIRNGVKSIGEKT EASLVWFTPPRTSNQWLDFW LRHRLQWWRKFAMSPSNFSS SDCQDEEGRKGNKLYYNFPW GKELIETLWNLGDHELLHMY PGNVSKLHGRDGRKNVVPCV LSVNGDLDRGMLAYLYDSFQ LTENSFTRKKNLHRKVLKLH PCLAPIKVALDVGRGPTLEL RQVCQGLFNELLENGISVWP GYLETMQSSLEQLYSKYDEM SILFTVLVTETTLENGLIH |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 216-485 of human POLG2 (NP_009146.2). |
| Function | Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. |
| Protein Name | Dna Polymerase Subunit Gamma-2Dna Polymerase Gamma Accessory 55 Kda SubunitP55Mitochondrial Dna Polymerase Accessory SubunitMtpolbPolg-Beta |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-9913635 |
| Cellular Localisation | MitochondrionMitochondrion MatrixMitochondrion Nucleoid |
| Alternative Antibody Names | Anti-Dna Polymerase Subunit Gamma-2 antibodyAnti-Dna Polymerase Gamma Accessory 55 Kda Subunit antibodyAnti-P55 antibodyAnti-Mitochondrial Dna Polymerase Accessory Subunit antibodyAnti-Mtpolb antibodyAnti-Polg-Beta antibodyAnti-POLG2 antibodyAnti-MTPOLB antibody |
Information sourced from Uniprot.org
