| Tissue Specificity | Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart. |
| Function | Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm. |
| Protein Name | Gdp-Fucose Protein O-Fucosyltransferase 2Peptide-O-Fucosyltransferase 2O-Fuct-2 |
| Database Links | Reactome: R-HSA-5173214 |
| Cellular Localisation | Endoplasmic ReticulumGolgi ApparatusMainly Located In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Gdp-Fucose Protein O-Fucosyltransferase 2 antibodyAnti-Peptide-O-Fucosyltransferase 2 antibodyAnti-O-Fuct-2 antibodyAnti-POFUT2 antibodyAnti-C21orf80 antibodyAnti-FUT13 antibodyAnti-KIAA0958 antibody |
Information sourced from Uniprot.org
