Anti-PLEKHA3 antibody (189-239 aa) (STJ195049)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PKHA3 at the amino acid range 189-239
General Information
| Short Description | Rabbit polyclonal anti-Pleckstrin homology domain-containing family A member 3 (189-239 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLEKHA3 |
| Gene ID | 65977 |
| Uniprot ID | PKHA3_HUMAN |
| Immunogen | Synthesized peptide derived from the human PKHA3 at the amino acid range 189-239 |
| Immunogen Region | 189-239 aa |
| Specificity | This antibody detects endogenous levels of PKHA3 at Human/Mouse |
Additional Info
| Function | Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane. Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration. Binds preferentially to PtdIns(4)P. Negatively regulates APOB secretion from hepatocytes. |
| Protein Name | Pleckstrin Homology Domain-Containing Family A Member 3Ph Domain-Containing Family A Member 3Phosphatidylinositol-Four-Phosphate Adapter Protein 1Fapp-1Phosphoinositol 4-Phosphate Adapter Protein 1 |
| Database Links | Reactome: R-HSA-1660499 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembranePeripheral Membrane ProteinLocalizes To Er-Trans Golgi Network (Tgn) Contacts Sites |
| Alternative Antibody Names | Anti-Pleckstrin Homology Domain-Containing Family A Member 3 antibodyAnti-Ph Domain-Containing Family A Member 3 antibodyAnti-Phosphatidylinositol-Four-Phosphate Adapter Protein 1 antibodyAnti-Fapp-1 antibodyAnti-Phosphoinositol 4-Phosphate Adapter Protein 1 antibodyAnti-PLEKHA3 antibodyAnti-FAPP1 antibody |
Information sourced from Uniprot.org