| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLCB3 |
| Gene ID: |
5331 |
| Uniprot ID: |
PLCB3_HUMAN |
| Immunogen Region: |
1010-1234 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1010-1234 of human PLC beta 3 (PLCB3) (NP_001303243.1). |
| Immunogen Sequence: |
GALGGAADVEDTKEGEDEAK RYQEFQNRQVQSLLELREAQ VDAEAQRRLEHLRQALQRLR EVVLDANTTQFKRLKEMNER EKKELQKILDRKRHNSISEA KMRDKHKKEAELTEINRRHI TESVNSIRRLEEAQKQRHDR LVAGQQQVLQQLAEEEPKLL AQLAQECQEQRARLPQEIRR SLLGEMPEGLGDGPLVACAS NGHAPGSSGHLSGADSESQE ENTQL |
| Function | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-3Phosphoinositide Phospholipase C-Beta-3Phospholipase C-Beta-3Plc-Beta-3 |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-1855204Reactome: R-HSA-399997Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-418217Reactome: R-HSA-434316Reactome: R-HSA-500657 |
| Cellular Localisation | CytoplasmMembraneNucleusAnd Particulate Fractions |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-3 antibodyAnti-Phosphoinositide Phospholipase C-Beta-3 antibodyAnti-Phospholipase C-Beta-3 antibodyAnti-Plc-Beta-3 antibodyAnti-PLCB3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
