Immunocytochemistry analysis of Phospho-lipase A2 Activator Protein (green) in Hela using Phospho-lipase A2 Activator Protein antibody, and DAPI (blue).

Anti-PLAA antibody (15-35 aa) [R06-1D7] (STJA0012681)

SKU:
STJA0012681-100
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ICC/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Phospholipase A2 Activator Protein (15-35 aa) is suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence research applications.
Clonality : Monoclonal
Clone ID : R06-1D7
Conjugation: Unconjugated
Isotype: IgG
Formulation: 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification: Affinity Purified
Concentration: 0.3 mg/ml
Dilution Range: WB 1:500-1:1000
IF 1:50-1:200
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: PLAA
Gene ID: 9373
Uniprot ID: PLAP_HUMAN
Immunogen Region: 15-35 aa
Immunogen: A synthetic peptide of human Anti-Phospholipase A2 activator protein (PLAP)
Function Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Protein Name Phospholipase A-2-Activating Protein
Pla2p
Plap
Cellular Localisation Nucleus
Cytoplasm
Synapse
Recruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains
Alternative Antibody Names Anti-Phospholipase A-2-Activating Protein antibody
Anti-Pla2p antibody
Anti-Plap antibody
Anti-PLAA antibody
Anti-PLAP antibody

Information sourced from Uniprot.org

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