Phospho-lipase A2 Activator Protein antibody immunocytochemistry HeLa cells STJA0012681

Anti-PLAA antibody (15-35 aa) [R06-1D7] (STJA0012681)

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STJA0012681-100
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Short Description :Rabbit monoclonal anti-Phospholipase A2 Activator Protein (15-35 aa) for use in WB, ICC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ICC/IF
Host:Rabbit
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :R06-1D7
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.3 mg/mL
Purification:Affinity Purified
Dilution Range:WB 1:500-1:1000
IF 1:50-1:200
Formulation:50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:PLAA
Gene ID:9373
Uniprot ID:PLAP_HUMAN
Immunogen:A synthetic peptide of human Anti-Phospholipase A2 activator protein (PLAP)
Immunogen Region:15-35 aa
Function Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Protein Name Phospholipase A-2-Activating Protein
Pla2p
Plap
Database Links
Cellular Localisation Nucleus
Cytoplasm
Synapse
Recruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains
Alternative Antibody Names Anti-Phospholipase A-2-Activating Protein antibody
Anti-Pla2p antibody
Anti-Plap antibody
Anti-PLAA antibody
Anti-PLAP antibody

Information sourced from Uniprot.org

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