| Function | Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis. In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs). |
| Protein Name | Cytosolic Phospholipase A2 ZetaCpla2-ZetaPhospholipase A2 Group Ivf |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922Reactome: R-HSA-1482925Reactome: R-HSA-1483115 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinMitochondrion |
| Alternative Antibody Names | Anti-Cytosolic Phospholipase A2 Zeta antibodyAnti-Cpla2-Zeta antibodyAnti-Phospholipase A2 Group Ivf antibodyAnti-PLA2G4F antibody |
Information sourced from Uniprot.org
