Anti-PKMYT1 antibody (49-98) (STJ94323)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human PKMYT1. AA range:49-98
General Information
| Short Description | Rabbit polyclonal anti-Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase (49-98) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PKMYT1 |
| Gene ID | 9088 |
| Uniprot ID | PMYT1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PKMYT1. AA range:49-98 |
| Immunogen Region | 49-98 |
| Specificity | Myt 1 Polyclonal Antibody detects endogenous levels of Myt 1 protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. |
| Function | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. |
| Protein Name | Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory KinaseMyt1 Kinase |
| Database Links | Reactome: R-HSA-156711Reactome: R-HSA-69273Reactome: R-HSA-69478 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory Kinase antibodyAnti-Myt1 Kinase antibodyAnti-PKMYT1 antibodyAnti-MYT1 antibody |
Information sourced from Uniprot.org