| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PKD1 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Pkd1 |
| Gene ID: |
18763 |
| Uniprot ID: |
PKD1_MOUSE |
| Specificity: |
Specific for PKD1. |
| Immunogen: |
A synthetic peptide from mouse PKD1 conjugated to blue carrier protein was used as the antigen. |
| Function | Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity. Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria. |
| Protein Name | Polycystin-1Autosomal Dominant Polycystic Kidney Disease 1 Protein Homolog |
| Database Links | Reactome: R-MMU-5620916 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumEndoplasmic ReticulumGolgi ApparatusVesicleSecretedExtracellular ExosomePkd1 Localization To The Plasma And Ciliary Membranes Requires Pkd2Is Independent Of Pkd2 Channel ActivityAnd Involves Stimulation Of Pkd1 Autocatalytic Cleavage At The Gps Region Of The Gain-B DomainPkd1:Pkd2 Interaction Is Required To Reach The Golgi Apparatus From Endoplasmic Reticulum And Then Traffic To The CiliaCiliary Localization Of Pkd1 Requires Bbs1 And Arl6/Bbs3Cell Surface Localization Requires GanabDetected On Migrasomes And On Extracellular Exosomes In Urine |
| Alternative Antibody Names | Anti-Polycystin-1 antibodyAnti-Autosomal Dominant Polycystic Kidney Disease 1 Protein Homolog antibodyAnti-Pkd1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
