| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Type 1 phosphatidylinositol 4, 5-bisphosphate 4-phosphatase is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIP4P1 |
| Gene ID: |
90809 |
| Uniprot ID: |
PP4P1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of TMEM55B at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human TMEM55B |
| Function | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules. Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1. May play a role in the regulation of cellular cholesterol metabolism. |
| Protein Name | Type 1 Phosphatidylinositol 4 -5-Bisphosphate 4-PhosphataseType 1 Ptdins-4 -5-P2 4-PtasePtdins-4 -5-P2 4-Ptase ITransmembrane Protein 55b |
| Database Links | Reactome: R-HSA-6811555Reactome: R-HSA-8847453 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome MembraneCytoplasmic VesiclePhagosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-Type 1 Phosphatidylinositol 4 -5-Bisphosphate 4-Phosphatase antibodyAnti-Type 1 Ptdins-4 -5-P2 4-Ptase antibodyAnti-Ptdins-4 -5-P2 4-Ptase I antibodyAnti-Transmembrane Protein 55b antibodyAnti-PIP4P1 antibodyAnti-C14orf9 antibodyAnti-TMEM55B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
