| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PILRA (20-180) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PILRA |
| Gene ID: |
29992 |
| Uniprot ID: |
PILRA_HUMAN |
| Immunogen Region: |
20-180 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PILRA (NP_840056.1). |
| Immunogen Sequence: |
QPSGSTGSGPSYLYGVTQPK HLSASMGGSVEIPFSFYYPW ELATAPDVRISWRRGHFHRQ SFYSTRPPSIHKDYVNRLFL NWTEGQKSGFLRISNLQKQD QSVYFCRVELDTRSSGRQQW QSIEGTKLSITQGQQRTKAT TPAREPFQNTEEPYENIRNE G |
| Tissue Specificity | Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC).preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. |
| Post Translational Modifications | N- and O-glycosylated. only N-glycosylated. Phosphorylated on tyrosine residues. |
| Function | Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1. |
| Protein Name | Paired Immunoglobulin-Like Type 2 Receptor AlphaCell Surface Receptor Fdf03Inhibitory Receptor Pilr-Alpha |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneIsoform 3: SecretedIsoform 4: Secreted |
| Alternative Antibody Names | Anti-Paired Immunoglobulin-Like Type 2 Receptor Alpha antibodyAnti-Cell Surface Receptor Fdf03 antibodyAnti-Inhibitory Receptor Pilr-Alpha antibodyAnti-PILRA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
