| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit delta isoform (41-90 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIK3CD |
| Gene ID: |
5293 |
| Uniprot ID: |
PK3CD_HUMAN |
| Immunogen Region: |
41-90 aa |
| Specificity: |
PI 3-Kinase p110 Delta Polyclonal Antibody detects endogenous levels of PI 3-Kinase p110 Delta protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the N-terminal region of human PIK3CD at the amino acid range 41-90 |
| Post Translational Modifications | Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity. |
| Function | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. |
| Protein Name | Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Delta IsoformPi3-Kinase Subunit DeltaPi3k-DeltaPi3kdeltaPtdins-3-Kinase Subunit DeltaPhosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit DeltaPtdins-3-Kinase Subunit P110-DeltaP110delta |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-1660499Reactome: R-HSA-2219530Reactome: R-HSA-512988Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-9027276Reactome: R-HSA-912526Reactome: R-HSA-912631Reactome: R-HSA-983695 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform antibodyAnti-Pi3-Kinase Subunit Delta antibodyAnti-Pi3k-Delta antibodyAnti-Pi3kdelta antibodyAnti-Ptdins-3-Kinase Subunit Delta antibodyAnti-Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Delta antibodyAnti-Ptdins-3-Kinase Subunit P110-Delta antibodyAnti-P110delta antibodyAnti-PIK3CD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
