| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Sumoylated. |
| Function | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus. |
| Protein Name | E3 Sumo-Protein Ligase Pias3E3 Sumo-Protein Transferase Pias3Protein Inhibitor Of Activated Stat Protein 3 |
| Database Links | Reactome: R-HSA-3232118Reactome: R-HSA-3899300Reactome: R-HSA-4090294Reactome: R-HSA-4615885Reactome: R-HSA-4755510Reactome: R-HSA-5696395 |
| Cellular Localisation | CytoplasmNucleusNucleus SpeckleColocalizes With Mitf In The NucleusColocalizes With Gfi1 In Nuclear DotsColocalizes With Sumo1 In Nuclear Granules |
| Alternative Antibody Names | Anti-E3 Sumo-Protein Ligase Pias3 antibodyAnti-E3 Sumo-Protein Transferase Pias3 antibodyAnti-Protein Inhibitor Of Activated Stat Protein 3 antibodyAnti-PIAS3 antibody |
Information sourced from Uniprot.org
