Anti-PHOX2B antibody (215-314) [S6MR] (STJ11102326)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal PHOX2B (215-314) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S6MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PHOX2B |
| Gene ID | 8929 |
| Uniprot ID | PHX2B_HUMAN |
| Immunogen Region | 215-314 |
| Immunogen Sequence | GGGPSPAGAPGAAGPGGPGG EPGKGGAAAAAAAAAAAAAA AAAAAAGGLAAAGGPGQGWA PGPGPITSIPDSLGGPFASV LSSLQRPNGAKAALVKSSMF |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 215-314 of human PHOX2B (NP_003915.2). |
Additional Info
| Tissue Specificity | Expressed in neuroblastoma, brain and adrenal gland. |
| Function | Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element. |
| Protein Name | Paired Mesoderm Homeobox Protein 2bNeuroblastoma PhoxNbphoxPhox2b Homeodomain ProteinPaired-Like Homeobox 2b |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Mesoderm Homeobox Protein 2b antibodyAnti-Neuroblastoma Phox antibodyAnti-Nbphox antibodyAnti-Phox2b Homeodomain Protein antibodyAnti-Paired-Like Homeobox 2b antibodyAnti-PHOX2B antibodyAnti-PMX2B antibody |
Information sourced from Uniprot.org