| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-Phospholipase C beta 1 for use in WB in Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R03-6E6 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: | Affinity Purified |
| Concentration: | 0.3 mg/mL |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | Plcb1 |
| Gene ID: | 18795 |
| Uniprot ID: | PLCB1_MOUSE |
| Immunogen: | Recombinant protein of mouse Phospholipase C beta 1 |
| Post Translational Modifications | Palmitoylated. Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier (Probable). Palmitoylation by ZDHHC21 is stimulated by inflammation. |
| Function | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-1Plc-154Phosphoinositide Phospholipase C-Beta-1Phospholipase C-Beta-1Plc-Beta-1 |
| Database Links | Reactome: R-MMU-112043Reactome: -MMU-1855204Reactome: -MMU-399997Reactome: -MMU-4086398Reactome: -MMU-416476Reactome: -MMU-418217Reactome: -MMU-434316Reactome: -MMU-500657 |
| Cellular Localisation | Nucleus MembraneCytoplasmColocalizes With The Adrenergic ReceptorsAdren1a And Adren1bAt The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-1 antibodyAnti-Plc-154 antibodyAnti-Phosphoinositide Phospholipase C-Beta-1 antibodyAnti-Phospholipase C-Beta-1 antibodyAnti-Plc-Beta-1 antibodyAnti-Plcb1 antibodyAnti-Plcb antibody |
Information sourced from Uniprot.org