| Host: | Rabbit |
| Applications: | WB/ICC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Vav2-Tyr-172 is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000 ICC 1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Vav2 |
| Gene ID: | 22325 |
| Uniprot ID: | VAV2_MOUSE |
| Specificity: | This antibody was cross-adsorbed to unphosphorylated Vav2 (Tyr-172) peptide before affinity purification using phospho-Vav2 (Tyr-172) peptide (without carrier). The antibody detects a 100 kDa* band corresponding to Vav on SDS-PAGE immunoblots of huma |
| Immunogen: | Phospho-Vav2 (Tyr-172) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-172 in mouse Vav2. This sequence has high homology with similar regions in rat and human Vav2, and has significant homology to the conserve |
| Function | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. |
| Protein Name | Guanine Nucleotide Exchange Factor Vav2 Vav-2 |
| Database Links | Reactome: R-MMU-114604 Reactome: -MMU-193648 Reactome: -MMU-2029482 Reactome: -MMU-2424491 Reactome: -MMU-2871796 Reactome: -MMU-2871809 Reactome: -MMU-3928665 Reactome: -MMU-416482 Reactome: -MMU-4420097 Reactome: -MMU-445144 Reactome: -MMU-5218920 Reactome: -MMU-8980692 Reactome: -MMU-9013026 Reactome: -MMU-9013106 Reactome: -MMU-9013148 Reactome: -MMU-9013149 Reactome: -MMU-9013404 Reactome: -MMU-9013408 Reactome: -MMU-9013423 Reactome: -MMU-9748787 |
| Alternative Antibody Names | Anti-Guanine Nucleotide Exchange Factor Vav2 antibody Anti-Vav-2 antibody Anti-Vav2 antibody |
Information sourced from Uniprot.org