| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Protein Tob1-Ser164 (130-179 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TOB1 |
| Gene ID: | 10140 |
| Uniprot ID: | TOB1_HUMAN |
| Immunogen Region: | 130-179 aa |
| Specificity: | Phospho-TOB1 (S164) Polyclonal Antibody detects endogenous levels of TOB1 protein only when phosphorylated at S164. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TOB1 around the phosphorylation site of Ser164 at the amino acid range 130-179 |
| Post Translational Modifications | Phosphorylated on Ser and Thr residues. |
| Function | Anti-proliferative protein.the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay. |
| Protein Name | Protein Tob1Transducer Of Erbb-2 1 |
| Cellular Localisation | CytoplasmNucleusOnly A Small Fraction Localizes To The Cytoplasm Except In Late S-Phase Where More Than Half Of Proteins Become Cytoplasmic |
| Alternative Antibody Names | Anti-Protein Tob1 antibodyAnti-Transducer Of Erbb-2 1 antibodyAnti-TOB1 antibodyAnti-TOB antibodyAnti-TROB1 antibody |
Information sourced from Uniprot.org