• Western blot of mouse hippocampal lysate showing specific immunolabeling of the ~65 kDa Munc18-1 protein phosphorylated at Ser241 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase ( Lambda-Ptase, 1200 units for 30 min).

Anti-Phospho-STXBP1-Ser241 antibody (STJA0003693)

SKU:
STJA0003693-100

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Host: Rabbit
Applications: WB/IHC
Reactivity: Mouse/Rat/Bovine/Canine/Chicken/Human/Non-Human Primates/Sheep
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Munc18-1-Ser241 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC 1:500
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Stxbp1
Gene ID: 20910
Uniprot ID: STXB1_MOUSE
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 conjugated to KLH.
Tissue Specificity Expressed in the inner and outer plexiform layers of the retina (at protein level).
Function Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes. May play a role in determining the specificity of intracellular fusion reactions.
Protein Name Syntaxin-Binding Protein 1
Protein Unc-18 Homolog 1
Unc18-1
Protein Unc-18 Homolog A
Unc-18a
Database Links Reactome: R-MMU-181429
Reactome: -MMU-181430
Reactome: -MMU-210500
Reactome: -MMU-212676
Reactome: -MMU-264642
Reactome: -MMU-888590
Cellular Localisation Cytoplasm
Cytosol
Membrane
Peripheral Membrane Protein
Alternative Antibody Names Anti-Syntaxin-Binding Protein 1 antibody
Anti-Protein Unc-18 Homolog 1 antibody
Anti-Unc18-1 antibody
Anti-Protein Unc-18 Homolog A antibody
Anti-Unc-18a antibody
Anti-Stxbp1 antibody

Information sourced from Uniprot.org

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