• Immunohistochemistry analysis of paraffin-embedded human lymph node, using RBL1 (Phospho-Thr369) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-RBL1-Thr369 antibody (335-384 aa) (STJ91140)

SKU:
STJ91140

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Retinoblastoma-like protein 1-Thr369 (335-384 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RBL1
Gene ID: 5933
Uniprot ID: RBL1_HUMAN
Immunogen Region: 335-384 aa
Specificity: Phospho-p107 (T369) Polyclonal Antibody detects endogenous levels of p107 protein only when phosphorylated at T369.
Immunogen: The antiserum was produced against synthesized peptide derived from the human RBL1 around the phosphorylation site of Thr369 at the amino acid range 335-384
Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.
Protein Name Retinoblastoma-Like Protein 1
107 Kda Retinoblastoma-Associated Protein
P107
Prb1
Database Links Reactome: R-HSA-1362277
Reactome: R-HSA-1362300
Reactome: R-HSA-1538133
Reactome: R-HSA-2173796
Reactome: R-HSA-6804114
Reactome: R-HSA-69205
Reactome: R-HSA-69231
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Retinoblastoma-Like Protein 1 antibody
Anti-107 Kda Retinoblastoma-Associated Protein antibody
Anti-P107 antibody
Anti-Prb1 antibody
Anti-RBL1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance