| Post Translational Modifications | Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions. |
| Function | Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase AlphaProtein-Tyrosine Phosphatase AlphaR-Ptp-Alpha |
| Database Links | Reactome: R-HSA-375165Reactome: R-HSA-5673001 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionFocal AdhesionLocalizes To Focal Adhesion Sites Following Integrin Engagement |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Alpha antibodyAnti-Protein-Tyrosine Phosphatase Alpha antibodyAnti-R-Ptp-Alpha antibodyAnti-PTPRA antibodyAnti-PTPA antibodyAnti-PTPRL2 antibody |
Information sourced from Uniprot.org
