| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-PDZ and LIM domain protein 5-Tyr251 is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDLIM5 |
| Gene ID: |
10611 |
| Uniprot ID: |
PDLI5_HUMAN |
| Specificity: |
Phospho-PDLIM5 (Y251) Polyclonal Antibody detects endogenous levels of PDLIM5 protein only when phosphorylated at Y251. |
| Immunogen: |
Synthesized phospho-peptide around the phosphorylation site of human PDLIM5 (phospho Tyr251) |
| Function | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. |
| Protein Name | Pdz And Lim Domain Protein 5Enigma HomologEnigma-Like Pdz And Lim Domains Protein |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Postsynaptic DensityPresynapsePostsynapseCytoplasmCytosolDetected Both At Presynaptic And Postsynaptic SitesExclusively At Excitatory SynapsesBut Not Inhibitory SynapsesIn Hippocampal Neurons |
| Alternative Antibody Names | Anti-Pdz And Lim Domain Protein 5 antibodyAnti-Enigma Homolog antibodyAnti-Enigma-Like Pdz And Lim Domains Protein antibodyAnti-PDLIM5 antibodyAnti-ENH antibodyAnti-L9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
