• Western blot with Anti-Phospho-PDE11A Antibody (S117 & S124) (STJ502595).

Anti-Phospho-PDE11A antibody (100-150) (STJ502595)

SKU:
STJ502595-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-PDE11A (100-150) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.69 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE11A
Gene ID: 50940
Uniprot ID: PDE11_HUMAN
Immunogen Region: 100-150
Immunogen: Synthetic peptide taken within amino acid region 100-150 on PDE11A protein. Phosphorylated Ser 117 & 124.
Tissue Specificity Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Protein Name Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a
Camp And Cgmp Phosphodiesterase 11a
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-418555
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a antibody
Anti-Camp And Cgmp Phosphodiesterase 11a antibody
Anti-PDE11A antibody

Information sourced from Uniprot.org

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