| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Nuclear migration protein nudC-Ser326 (282-331 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUDC |
| Gene ID: | 10726 |
| Uniprot ID: | NUDC_HUMAN |
| Immunogen Region: | 282-331 aa |
| Specificity: | Phospho-NUDC (S326) Polyclonal Antibody detects endogenous levels of NUDC protein only when phosphorylated at S326. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human NudC around the phosphorylation site of Ser326 at the amino acid range 282-331 |
| Post Translational Modifications | Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases. |
| Function | Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. |
| Protein Name | Nuclear Migration Protein NudcNuclear Distribution Protein C Homolog |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusSpindleMidbodyIn A Filamentous Pattern Adjacent To The Nucleus Of Migrating Cerebellar Granule CellsColocalizes With Tubulin And Dynein And With The Microtubule Organizing CenterDistributed Throughout The Cytoplasm Of Non-Migrating CellsA Small Proportion Is NuclearIn A Punctate PatternLocalizes To The Mitotic Spindle In A Eml4-Dependent Manner |
| Alternative Antibody Names | Anti-Nuclear Migration Protein Nudc antibodyAnti-Nuclear Distribution Protein C Homolog antibodyAnti-NUDC antibody |
Information sourced from Uniprot.org
