| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Leukocyte tyrosine kinase receptor-Tyr672/Tyr1278 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LTK |
| Gene ID: |
4058 |
| Uniprot ID: |
LTK_HUMAN |
| Specificity: |
This antibody detects endogenous levels of LTK/ALK (Phospho-Tyr672/Tyr1278) at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human LTK/ALK (Phospho-Tyr672/Tyr1278) |
| Tissue Specificity | Expressed in non-hematopoietic cell lines and T- and B-cell lines. |
| Post Translational Modifications | Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. |
| Function | Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. The exact function of this protein is not known.studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. |
| Protein Name | Leukocyte Tyrosine Kinase ReceptorProtein Tyrosine Kinase 1 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Tyrosine Kinase Receptor antibodyAnti-Protein Tyrosine Kinase 1 antibodyAnti-LTK antibodyAnti-TYK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
