Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Phospho-LCP2-Y145 is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
LCP2 |
Gene ID: |
3937 |
Uniprot ID: |
LCP2_HUMAN |
Immunogen: |
A synthetic phosphorylated peptide around Y145 of human LCP2 (NP_005556.1). |
Immunogen Sequence: |
ADYEP |
Tissue Specificity | Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. |
Post Translational Modifications | Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components. |
Function | Involved in T-cell antigen receptor mediated signaling. |
Protein Name | Lymphocyte Cytosolic Protein 2Sh2 Domain-Containing Leukocyte Protein Of 76 KdaSlp-76 Tyrosine PhosphoproteinSlp76 |
Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202433Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Lymphocyte Cytosolic Protein 2 antibodyAnti-Sh2 Domain-Containing Leukocyte Protein Of 76 Kda antibodyAnti-Slp-76 Tyrosine Phosphoprotein antibodyAnti-Slp76 antibodyAnti-LCP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance