Host: | Rabbit |
Applications: | WB/ELISA/IHC |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Phospho-Plastin-2-Tyr28 is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | LCP1 |
Gene ID: | 3936 |
Uniprot ID: | PLSL_HUMAN |
Specificity: | This antibody detects endogenous levels of Human LCP1 (phospho-Tyr28) |
Immunogen: | Synthesized phosho peptide around human LCP1 (Tyr28) |
Post Translational Modifications | Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections. |
Function | Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. |
Protein Name | Plastin-2 L-Plastin Lc64p Lymphocyte Cytosolic Protein 1 Lcp-1 |
Database Links | Reactome: R-HSA-8950505 |
Cellular Localisation | Cytoplasm Cytoskeleton Cell Junction Cell Projection Ruffle Membrane Peripheral Membrane Protein Cytoplasmic Side Relocalizes To The Immunological Synapse Between Peripheral Blood T-Lymphocytes And Antibody-Presenting Cells In Response To Costimulation Through Tcr/Cd3 And Cd2 Or Cd28 Associated With The Actin Cytoskeleton At Membrane Ruffles Relocalizes To Actin-Rich Cell Projections Upon Serine Phosphorylation |
Alternative Antibody Names | Anti-Plastin-2 antibody Anti-L-Plastin antibody Anti-Lc64p antibody Anti-Lymphocyte Cytosolic Protein 1 antibody Anti-Lcp-1 antibody Anti-LCP1 antibody Anti-PLS2 antibody |
Information sourced from Uniprot.org