| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Serine protease HTRA2, mitochondrial-Ser212 (181-230 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HTRA2 |
| Gene ID: |
27429 |
| Uniprot ID: |
HTRA2_HUMAN |
| Immunogen Region: |
181-230 aa |
| Specificity: |
Phospho-HtrA2 (S212) Polyclonal Antibody detects endogenous levels of HtrA2 protein only when phosphorylated at S212. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human HtrA2 around the phosphorylation site of Ser212 at the amino acid range 181-230 |
| Post Translational Modifications | Autoproteolytically activated. |
| Function | Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. |
| Protein Name | Serine Protease Htra2 - MitochondrialHigh Temperature Requirement Protein A2Htra2Omi Stress-Regulated EndoproteaseSerine Protease 25Serine Proteinase Omi |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MembraneSingle-Pass Membrane ProteinPredominantly Present In The Intermembrane SpaceReleased Into The Cytosol Following Apoptotic StimuliSuch As Uv TreatmentAnd Stimulation Of Mitochondria With Caspase-8 Truncated Bid/TbidIsoform 1: Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Serine Protease Htra2 - Mitochondrial antibodyAnti-High Temperature Requirement Protein A2 antibodyAnti-Htra2 antibodyAnti-Omi Stress-Regulated Endoprotease antibodyAnti-Serine Protease 25 antibodyAnti-Serine Proteinase Omi antibodyAnti-HTRA2 antibodyAnti-OMI antibodyAnti-PRSS25 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
