| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Beta-adrenergic receptor kinase 1-Ser685 (640-689 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRK2 |
| Gene ID: |
156 |
| Uniprot ID: |
ARBK1_HUMAN |
| Immunogen Region: |
640-689 aa |
| Specificity: |
Phospho-GRK 2 (S685) Polyclonal Antibody detects endogenous levels of GRK 2 protein only when phosphorylated at S685. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human GRK2 around the phosphorylation site of Ser685 at the amino acid range 640-689 |
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light. |
| Protein Name | Beta-Adrenergic Receptor Kinase 1Beta-Ark-1G-Protein Coupled Receptor Kinase 2 |
| Database Links | Reactome: R-HSA-111933Reactome: R-HSA-416476Reactome: R-HSA-418555Reactome: R-HSA-5635838Reactome: R-HSA-8856825 |
| Cellular Localisation | CytoplasmCell MembranePostsynapsePresynapse |
| Alternative Antibody Names | Anti-Beta-Adrenergic Receptor Kinase 1 antibodyAnti-Beta-Ark-1 antibodyAnti-G-Protein Coupled Receptor Kinase 2 antibodyAnti-GRK2 antibodyAnti-ADRBK1 antibodyAnti-BARK antibodyAnti-BARK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
