| Host: |
Rabbit |
| Applications: |
WB/IHC/ICC |
| Reactivity: |
Mouse/Rat/Bovine/Canine/Chicken/Human/Non-Human Primates/Xenopus |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-GABAB Receptor-Ser783 is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: |
This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: |
WB 1:1000IHC 1:500ICC 1:500IP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Gabbr2 |
| Gene ID: |
83633 |
| Uniprot ID: |
GABR2_RAT |
| Immunogen: |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser783 conjugated to KLH. |
| Tissue Specificity | Highly expressed in areas of the brain including thalamic nuclei, the hippocampus, cerebellar Purkinje cells and the medial habenula, and moderately expressed in the cerebral cortex, certain anterioventral thalamic nuclei, dorsal medial hypothalamic nucleus and suprachiasmatic nuclei. Also weakly expressed in the testis. |
| Function | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. |
| Protein Name | Gamma-Aminobutyric Acid Type B Receptor Subunit 2Gaba-B Receptor 2Gaba-B-R2Gaba-Br2Gababr2Gb2G-Protein Coupled Receptor 51 |
| Database Links | Reactome: R-RNO-1296041Reactome: -RNO-418594Reactome: -RNO-420499Reactome: -RNO-977444Reactome: -RNO-997272 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePerikaryonCell ProjectionDendriteCoexpression Of Gabbr1 And Gabbr2 Is Required For Gabbr1 Maturation And Transport To The Plasma MembraneIn ContrastGabbr2 Does Not Depend On Gabbr1 For Transport To The Cell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Type B Receptor Subunit 2 antibodyAnti-Gaba-B Receptor 2 antibodyAnti-Gaba-B-R2 antibodyAnti-Gaba-Br2 antibodyAnti-Gababr2 antibodyAnti-Gb2 antibodyAnti-G-Protein Coupled Receptor 51 antibodyAnti-Gabbr2 antibodyAnti-Gpr51 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
