• Immunohistochemistry analysis of paraffin-embedded human brain, using CtBP1 (Phospho-Ser422) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of lysates from Jurkat cells treated with TNF 20ng/ml 30' and Jurkat cells treated with UV 15', using CtBP1 (Phospho-Ser422) Antibody. The lane on the right is blocked with the phospho peptide.
  • Western blot analysis of JK cells using Phospho-CtBP1 (S422) Polyclonal Antibody

Anti-Phospho-CTBP1-Ser422 antibody (388-437 aa) (STJ90975)

SKU:
STJ90975

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-C-terminal-binding protein 1-Ser422 (388-437 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTBP1
Gene ID: 1487
Uniprot ID: CTBP1_HUMAN
Immunogen Region: 388-437 aa
Specificity: Phospho-CtBP1 (S422) Polyclonal Antibody detects endogenous levels of CtBP1 protein only when phosphorylated at S422.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CtBP1 around the phosphorylation site of Ser422 at the amino acid range 388-437
Post Translational Modifications The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation. ADP-ribosylated.when cells are exposed to brefeldin A. Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.
Function Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
Protein Name C-Terminal-Binding Protein 1
Ctbp1
Database Links Reactome: R-HSA-3769402
Reactome: R-HSA-3899300
Reactome: R-HSA-4641265
Reactome: R-HSA-5339700
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-C-Terminal-Binding Protein 1 antibody
Anti-Ctbp1 antibody
Anti-CTBP1 antibody
Anti-CTBP antibody

Information sourced from Uniprot.org

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