Anti-Phospho-CAVIN1-Tyr156 antibody (STJA0009988)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PTRF (Phospho-Tyr156)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Caveolae-associated protein 1-Tyr156 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CAVIN1 |
| Gene ID | 284119 |
| Uniprot ID | CAVN1_HUMAN |
| Immunogen | Synthesized peptide derived from human PTRF (Phospho-Tyr156) |
| Specificity | This antibody detects endogenous levels of PTRF (Phospho-Tyr156) at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity. Phosphorylation at Tyr-156 is essential for its functionin the regulation of ribosomal transcriptional activity. Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent. Monoubiquitinated. |
| Function | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A. |
| Protein Name | Caveolae-Associated Protein 1Cavin-1Polymerase I And Transcript Release Factor |
| Database Links | Reactome: R-HSA-73863Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | MembraneCaveolaCell MembraneMicrosomeEndoplasmic ReticulumCytoplasmCytosolMitochondrionNucleusTranslocates To The Cytoplasm From The Caveolae Upon Insulin StimulationColocalizes With Cav1 In Lipid Rafts In AdipocytesLocalizes In The Caveolae In A Caveolin-Dependent Manner |
| Alternative Antibody Names | Anti-Caveolae-Associated Protein 1 antibodyAnti-Cavin-1 antibodyAnti-Polymerase I And Transcript Release Factor antibodyAnti-CAVIN1 antibodyAnti-PTRF antibodyAnti-FKSG13 antibody |
Information sourced from Uniprot.org