| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Calpain-2 catalytic subunit-Ser50 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CAPN2 |
| Gene ID: |
824 |
| Uniprot ID: |
CAN2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Human, Mouse, Rat Calpain 2 (Phospho Ser50) |
| Immunogen: |
Synthesized peptide derived from human Calpain 2 (Phospho Ser50) |
| Tissue Specificity | Ubiquitous. |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. |
| Protein Name | Calpain-2 Catalytic SubunitCalcium-Activated Neutral Proteinase 2Canp 2Calpain M-TypeCalpain Large Polypeptide L2Calpain-2 Large SubunitMillimolar-CalpainM-Calpain |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-8862803 |
| Cellular Localisation | CytoplasmCell MembraneTranslocates To The Plasma Membrane Upon Ca(2+) Binding |
| Alternative Antibody Names | Anti-Calpain-2 Catalytic Subunit antibodyAnti-Calcium-Activated Neutral Proteinase 2 antibodyAnti-Canp 2 antibodyAnti-Calpain M-Type antibodyAnti-Calpain Large Polypeptide L2 antibodyAnti-Calpain-2 Large Subunit antibodyAnti-Millimolar-Calpain antibodyAnti-M-Calpain antibodyAnti-CAPN2 antibodyAnti-CANPL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
