Anti-Phospho-Acetyl CoA Carboxylase 1-S79-S79 antibody [SRM15134] (STJ11109864)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal Phospho-Acetyl CoA Carboxylase 1-S79-S79 antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM15134 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:1000-1:2000IF/ICC, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACACA |
| Gene ID | 31 |
| Uniprot ID | ACACA_HUMAN |
| Immunogen | Synthetic peptide. This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues.expressed at low level in pulmonary tissue.not detected in the liver. |
| Post Translational Modifications | Phosphorylation on Ser-1263 is required for interaction with BRCA1. Phosphorylation at Ser-80 by AMPK inactivates enzyme activity. The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. |
| Function | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. |
| Protein Name | Acetyl-Coa Carboxylase 1Acc1Acetyl-Coenzyme A Carboxylase AlphaAcc-Alpha |
| Database Links | Reactome: R-HSA-163765Reactome: R-HSA-196780Reactome: R-HSA-200425Reactome: R-HSA-2426168Reactome: R-HSA-3371599Reactome: R-HSA-75105 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Acetyl-Coa Carboxylase 1 antibodyAnti-Acc1 antibodyAnti-Acetyl-Coenzyme A Carboxylase Alpha antibodyAnti-Acc-Alpha antibodyAnti-ACACA antibodyAnti-ACAC antibodyAnti-ACC1 antibodyAnti-ACCA antibody |
Information sourced from Uniprot.org