| Short Description : | Rabbit polyclonal anti-PHD finger protein 21A for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHF21A |
| Gene ID: | 51317 |
| Uniprot ID: | PF21A_HUMAN |
| Immunogen: | Synthesized peptide derived from human PHF21A |
| Specificity: | This antibody detects endogenous levels of PHF21A at Human, Mouse |
| Function | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. |
| Protein Name | Phd Finger Protein 21aBhc80aBraf35-Hdac Complex Protein Bhc80 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-9679191Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Phd Finger Protein 21a antibodyAnti-Bhc80a antibodyAnti-Braf35-Hdac Complex Protein Bhc80 antibodyAnti-PHF21A antibodyAnti-BHC80 antibodyAnti-KIAA1696 antibodyAnti-BM-006 antibody |
Information sourced from Uniprot.org
