Anti-PHEX antibody (STJA0009736)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PHEX
General Information
| Short Description | Rabbit polyclonal anti-Phosphate-regulating neutral endopeptidase PHEX for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PHEX |
| Gene ID | 5251 |
| Uniprot ID | PHEX_HUMAN |
| Immunogen | Synthesized peptide derived from human PHEX |
| Specificity | This antibody detects endogenous levels of PHEX at Human, Mouse |
Additional Info
| Function | Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation. |
| Protein Name | Phosphate-Regulating Neutral Endopeptidase PhexMetalloendopeptidase Homolog PexVitamin D-Resistant Hypophosphatemic Rickets ProteinX-Linked Hypophosphatemia ProteinHyp |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Phosphate-Regulating Neutral Endopeptidase Phex antibodyAnti-Metalloendopeptidase Homolog Pex antibodyAnti-Vitamin D-Resistant Hypophosphatemic Rickets Protein antibodyAnti-X-Linked Hypophosphatemia Protein antibodyAnti-Hyp antibodyAnti-PHEX antibodyAnti-PEX antibody |
Information sourced from Uniprot.org