| Short Description : | Rabbit polyclonal PHC2 (250-323) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHC2 |
| Gene ID: | 1912 |
| Uniprot ID: | PHC2_HUMAN |
| Immunogen Region: | 250-323 |
| Immunogen Sequence: | HFLPSEPTKWNVEDVYEFIR SLPGCQEIAEEFRAQEIDGQ ALLLLKEDHLMSAMNIKLGP ALKIYARISMLKDS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-323 of human PHC2 (NP_004418.2). |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Protein Name | Polyhomeotic-Like Protein 2Hph2Early Development Regulatory Protein 2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724 |
| Cellular Localisation | NucleusCo-Localizes With Samd7 In Nuclear Polycomb Bodies |
| Alternative Antibody Names | Anti-Polyhomeotic-Like Protein 2 antibodyAnti-Hph2 antibodyAnti-Early Development Regulatory Protein 2 antibodyAnti-PHC2 antibodyAnti-EDR2 antibodyAnti-PH2 antibody |
Information sourced from Uniprot.org
