Anti-PGRP-S antibody (C-Term) (STJ71316)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PGRP-S (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 30kDa band observed in lysates of cell line Jurkat (calculated MW of 21.7kDa according to NP_005082.1). The observed molecular weight corresponds to earlier findings in literatur |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PGLYRP1 |
| Gene ID | 8993 |
| Uniprot ID | PGRP1_HUMAN |
| Accession Number | NP_005082.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | PGNQLYHLIQN |
Additional Info
| Post Translational Modifications | N-glycosylated. N-glycosylation is required for bactericidal activity. |
| Function | Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor. |
| Protein Name | Peptidoglycan Recognition Protein 1Peptidoglycan Recognition Protein ShortPgrp-S |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedCytoplasmic Granule |
| Alternative Antibody Names | Anti-Peptidoglycan Recognition Protein 1 antibodyAnti-Peptidoglycan Recognition Protein Short antibodyAnti-Pgrp-S antibodyAnti-PGLYRP1 antibodyAnti-PGLYRP antibodyAnti-PGRP antibodyAnti-TNFSF3L antibodyAnti-SBBI68 antibodyAnti-UNQ639 antibodyAnti-PRO1269 antibody |
Information sourced from Uniprot.org