Anti-PGRMC1 antibody (20-100 aa) (STJ190957)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 20-100
General Information
| Short Description | Rabbit polyclonal anti-Membrane-associated progesterone receptor component 1 (20-100 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PGRMC1 |
| Gene ID | 10857 |
| Uniprot ID | PGRC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 20-100 |
| Immunogen Region | 20-100 aa |
| Specificity | PGRC1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate attached to Ser-54. Ser-54 is in the cytoplasmic domain but the glycosylated form was detected in urine, suggesting that the membrane-bound form is cleaved, allowing for production of a secreted form which is glycosylated. |
| Function | Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization. |
| Protein Name | Membrane-Associated Progesterone Receptor Component 1MprDap1Iza |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Microsome MembraneSingle-Pass Membrane ProteinSmooth Endoplasmic Reticulum MembraneMitochondrion Outer MembraneExtracellular SideSecretedLocalized At Cell MembraneProbably In Lipid RaftsIn Serum-Starved Conditions |
| Alternative Antibody Names | Anti-Membrane-Associated Progesterone Receptor Component 1 antibodyAnti-Mpr antibodyAnti-Dap1 antibodyAnti-Iza antibodyAnti-PGRMC1 antibodyAnti-HPR6.6 antibodyAnti-PGRMC antibody |
Information sourced from Uniprot.org