Anti-PEAR1 antibody (910-990 aa) (STJ192402)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 910-990
General Information
| Short Description | Rabbit polyclonal anti-Platelet endothelial aggregation receptor 1 (910-990 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PEAR1 |
| Gene ID | 375033 |
| Uniprot ID | PEAR1_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 910-990 |
| Immunogen Region | 910-990 aa |
| Specificity | PEAR1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated in the intracellular domain on tyrosine residues. Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2. Phosphorylated when in the presence of SVEP1. |
| Function | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. May be involved in the early stages of hematopoiesis. |
| Protein Name | Platelet Endothelial Aggregation Receptor 1Hpear1Multiple Epidermal Growth Factor-Like Domains Protein 12Multiple Egf-Like Domains Protein 12 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCell ProjectionLamellipodiumDetected On The Cell Surface In Resting Platelets |
| Alternative Antibody Names | Anti-Platelet Endothelial Aggregation Receptor 1 antibodyAnti-Hpear1 antibodyAnti-Multiple Epidermal Growth Factor-Like Domains Protein 12 antibodyAnti-Multiple Egf-Like Domains Protein 12 antibodyAnti-PEAR1 antibodyAnti-MEGF12 antibody |
Information sourced from Uniprot.org