Anti-PDZK1 antibody [R07-2A6] (STJA0034704)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human PDZK1
General Information
| Short Description | Rabbit monoclonal anti-PDZK1 for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-2A6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PDZK1 |
| Gene ID | 5174 |
| Uniprot ID | NHRF3_HUMAN |
| Immunogen | A synthetic peptide of human PDZK1 |
Additional Info
| Tissue Specificity | Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas. |
| Function | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3Nherf-3Cftr-Associated Protein Of 70 KdaNa(+/H(+ Exchanger Regulatory Factor 3Na/Pi Cotransporter C-Terminal-Associated Protein 1Napi-Cap1Pdz Domain-Containing Protein 1Sodium-Hydrogen Exchanger Regulatory Factor 3 |
| Database Links | |
| Cellular Localisation | MembranePeripheral Membrane ProteinCell MembraneAssociated With Peripheral MembranesLocalizes To The Apical Compartment Of Proximal Tubular Cells And To Sinusoidal Liver Membranes |
| Alternative Antibody Names | Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3 antibodyAnti-Nherf-3 antibodyAnti-Cftr-Associated Protein Of 70 Kda antibodyAnti-Na(+/H(+ Exchanger Regulatory Factor 3 antibodyAnti-Na/Pi Cotransporter C-Terminal-Associated Protein 1 antibodyAnti-Napi-Cap1 antibodyAnti-Pdz Domain-Containing Protein 1 antibodyAnti-Sodium-Hydrogen Exchanger Regulatory Factor 3 antibodyAnti-PDZK1 antibodyAnti-CAP70 antibodyAnti-NHERF3 antibodyAnti-PDZD1 antibody |
Information sourced from Uniprot.org