Anti-PDIA6 antibody (STJA0006902)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PDIA6
General Information
| Short Description | Rabbit polyclonal anti-Protein disulfide-isomerase A6 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDIA6 |
| Gene ID | 10130 |
| Uniprot ID | PDIA6_HUMAN |
| Immunogen | Synthesized peptide derived from human PDIA6 |
| Specificity | This antibody detects endogenous levels of PDIA6 at Human, Mouse, Rat |
Additional Info
| Function | May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. |
| Protein Name | Protein Disulfide-Isomerase A6Endoplasmic Reticulum Protein 5Er Protein 5Erp5Protein Disulfide Isomerase P5Thioredoxin Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-381038Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum LumenCell MembraneMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Protein Disulfide-Isomerase A6 antibodyAnti-Endoplasmic Reticulum Protein 5 antibodyAnti-Er Protein 5 antibodyAnti-Erp5 antibodyAnti-Protein Disulfide Isomerase P5 antibodyAnti-Thioredoxin Domain-Containing Protein 7 antibodyAnti-PDIA6 antibodyAnti-ERP5 antibodyAnti-P5 antibodyAnti-TXNDC7 antibody |
Information sourced from Uniprot.org