| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDE4DIP (1-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDE4DIP |
| Gene ID: |
9659 |
| Uniprot ID: |
MYOME_HUMAN |
| Immunogen Region: |
1-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human PDE4DIP (NP_071754.3). |
| Immunogen Sequence: |
MKGTDSGSCCRRRCDFGCCC RASRRAHYTPYRSGDATRTP QSPRQTPSRERRRPEPAGSW AAAAEEEEAAAAATPWMRDY FAEDDGEMVPRTSHTAAFLS DTKDRGPPVQSQIWRSGEKV PFVQTYSLRAFEKPPQVQTQ ALRDFEKHLNDLKKENFSLK LRIYFLEERMQQKYEASRED IYKRNIELKVEVESLKRELQ DKKQHLDKTWADVENLNSQN EAELRRQFEERQQETEHVY |
| Tissue Specificity | Highly expressed in adult and fetal heart, in skeletal muscle and, to a lower extent, in brain and placenta. |
| Function | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. Isoform 13: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression. |
| Protein Name | MyomegalinCardiomyopathy-Associated Protein 2Phosphodiesterase 4d-Interacting Protein |
| Cellular Localisation | Golgi ApparatusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeIsoform 13: CytoplasmAssociated With The Microtubule Network At The Growing Distal Tip Of MicrotubulesTargeting To The Golgi Apparatus Requires Akap9 |
| Alternative Antibody Names | Anti-Myomegalin antibodyAnti-Cardiomyopathy-Associated Protein 2 antibodyAnti-Phosphodiesterase 4d-Interacting Protein antibodyAnti-PDE4DIP antibodyAnti-CMYA2 antibodyAnti-KIAA0454 antibodyAnti-KIAA0477 antibodyAnti-MMGL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
