| Tissue Specificity | Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. |
| Post Translational Modifications | Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation. Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens.phosphorylation promotes proteasomal degradation of PDCD4. |
| Function | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. |
| Protein Name | Programmed Cell Death Protein 4Neoplastic Transformation Inhibitor ProteinNuclear Antigen H731-LikeProtein 197/15a |
| Database Links | Reactome: R-HSA-8950505 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And CytoplasmPredominantly Nuclear Under Normal Growth ConditionsAnd When Phosphorylated At Ser-457 |
| Alternative Antibody Names | Anti-Programmed Cell Death Protein 4 antibodyAnti-Neoplastic Transformation Inhibitor Protein antibodyAnti-Nuclear Antigen H731-Like antibodyAnti-Protein 197/15a antibodyAnti-PDCD4 antibodyAnti-H731 antibody |
Information sourced from Uniprot.org
![Immunohistochemistry analysis of PDCD4 in paraffin-embedded human placenta using [KO Validated] PDCD4 Rabbit polyclonal antibody (STJ24925) at dilution of 1:20 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/100232/386432/STJ24925_1__57951.1713155506.jpg?c=1 "Immunohistochemistry analysis of PDCD4 in paraffin-embedded human placenta using [KO Validated] PDCD4 Rabbit polyclonal antibody (STJ24925) at dilution of 1:20 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")