Anti-PAX6 antibody [R08-8F3] (STJA0036170)

Name: Anti-PAX6 antibody [R08-8F3] (STJA0036170)
SKU: STJA0036170
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SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenA synthesized peptide derived from human PAX6

STJA0036170

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Short Description	Rabbit monoclonal anti-PAX6 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ICC/IF
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	R08-8F3
Isotype	IgG
Conjugation	Unconjugated
Purification	Affinity Chromatography
Dilution Range	WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:200
Formulation	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction	Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.

Gene Symbol	PAX6
Gene ID	5080
Uniprot ID	PAX6_HUMAN
Immunogen	A synthesized peptide derived from human PAX6

Tissue Specificity	Isoform 1: Expressed in lymphoblasts. Isoform 5a: Weakly expressed in lymphoblasts.
Post Translational Modifications	Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.
Function	Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression.
Protein Name	Paired Box Protein Pax-6 Aniridia Type Ii Protein Oculorhombin
Database Links	Reactome: R-HSA-210745 Reactome: R-HSA-381771 Reactome: R-HSA-400511 Reactome: R-HSA-5617472 Reactome: R-HSA-9823739
Cellular Localisation	Nucleus Isoform 1: Nucleus Isoform 5a: Nucleus
Alternative Antibody Names	Anti-Paired Box Protein Pax-6 antibody Anti-Aniridia Type Ii Protein antibody Anti-Oculorhombin antibody Anti-PAX6 antibody Anti-AN2 antibody

Information sourced from Uniprot.org