• Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Prostate Apoptosis Response protein-4 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from NIH/3T3 cells, using Prostate Apoptosis Response protein-4 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using PAR4 Polyclonal Antibody

Anti-PAWR antibody (291-340 aa) (STJ94952)

SKU:
STJ94952

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PRKC apoptosis WT1 regulator protein (291-340 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PAWR
Gene ID: 5074
Uniprot ID: PAWR_HUMAN
Immunogen Region: 291-340 aa
Specificity: PAR4 Polyclonal Antibody detects endogenous levels of PAR4 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Prostate Apoptosis Response protein-4 at the amino acid range 291-340
Post Translational Modifications Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
Function Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Protein Name Prkc Apoptosis Wt1 Regulator Protein
Prostate Apoptosis Response 4 Protein
Par-4
Cellular Localisation Cytoplasm
Nucleus
Mainly Cytoplasmic In Absence Of Apoptosis Signal And In Normal Cells
Nuclear In Most Cancer Cell Lines
Nuclear Entry Seems To Be Essential But Not Sufficient For Apoptosis
Nuclear Localization Includes Nucleoplasm And Pml Nuclear Bodies
Alternative Antibody Names Anti-Prkc Apoptosis Wt1 Regulator Protein antibody
Anti-Prostate Apoptosis Response 4 Protein antibody
Anti-Par-4 antibody
Anti-PAWR antibody
Anti-PAR4 antibody

Information sourced from Uniprot.org

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